I would tend to think that the more bright colors it has would have a bearing on
what was in the ink. Certain colors would probably require some exotic dyes. Many people also worry about the glues in corrugated boxes.
There are many opinions on it (here and elsewhere). Many use it with no qualms, while others wouldn't let it near their soil. I'm sure different printers use different inks, but how do we know which are OK or not. Some printers have the habit of pointing out that their inks are safe, but I have never seen anybody point out "This ink will destroy anything in its path. Keep box away from children."
I believe that everybody
should do their own research on it, and make their decisions based on 'comfort zone.
I guess that the bottom line is that if it makes
you uncomfortable, DON'T use it.