Reversible inhibition of sperm under guidance (RISUG), formerly referred to as the synthetic polymer styrene maleic anhydride (SMA), is the development name of a male contraceptive developed at IIT Kharagpur in India by Dr. Sujoy K Guha. Phase III clinical trials are underway in India, slowed by insufficient volunteers. It has been patented in India, China, Bangladesh, and the United States. In the United States, there are efforts to get FDA approval under the name Vasalgel.
AdvantagesSome of the advantages, according to Dr. Guha, are:
Effectiveness - There has been only one unplanned pregnancy among partners of the 250 men who have been injected RISUG — apparently due to an improperly administered injection. Out of the 250 men who have been injected RISUG, 15 men received the injection more than 10 years ago.
Convenience - There is no interruption before the sexual act.
Outpatient Procedure - Men can leave the hospital immediately after an injection and resume their normal sex lives within a week.
Duration of effect - According to Dr. Guha, a single 60 mg injection can be effective for at least 10 years.
Reduced side effects - After testing RISUG on more than 250 volunteers, neither Guha nor other researchers in the field report side effects other than a slight scrotal swelling in some men immediately following the injection, which goes away after a few weeks, though there are also unconfirmed reports of kidney problems (see Controversy section below for further details). Also, because sperm can still exit the body unimpeded, patients don’t experience the pressure or granulomas that can result from vasectomy.
Reversibility - The contraceptive action appears to be reversible by flushing the vas deferens with another injection of dimethyl sulfoxide or sodium bicarbonate solution. (The sodium bicarbonate solution cannot be used as the solvent in the initial injection since it would neutralize the positive charge effect.) Although this reversal procedure has been tried only on primates, it has been repeatedly successful. Unlike in a vasectomy (see Blood-testis barrier), the vas deferens is not completely blocked, the body doesn't have to absorb the blocked sperm, and sperm antibodies are not produced in large numbers, making successful reversal more likely than with a vasovasostomy.
Lisa Allen wrote:Also, the lady in Sweden used it ALL the time.
Bradley Laughlin wrote:My fertility is one of the things that I value about myself the most... I'd never undergo something like this. I just can't see any other perspective on the issue. Condoms work just fine for me.
Hem... I think this sort of thinking may be behind the burgeoning over-population on the planet.
myth behind "pulling out" in time