Michael, two (three?) bits of advice about weeding that make sense to me (though I too, have trouble with follow through on) are:
Work a small area at first (plot A) then go over plot A again, before adding plot B. Then go over plots A & B before adding plot C...etc... This way you can maintain your progress, rather than chasing your tail, since you keep going back to plot A, etc... to get what you missed or what sprouts again, until it is gone.
Another version of this that was successful for us in eradicating bull thistle was longitudinal... Year 1: we dug up at least 3 dozen thistles, some were 6 feet tall. Year 2: we dug up a couple dozen more, but they were smaller, mostly knee-high or less. Year 3: we dug maybe a half dozen? mostly low rosettes. Now, 10 years on, we maybe see one now and then. Which is maybe more about the next point...
Don't allow it to get worse. Especially by allowing the "weed" to go to seed, but also not allowing it to grow bigger, or to spread further by runners/vines.
Cutting back the aerial growth sets the plant back, and prevents more/worse chores of untangling vines from crops,
trees, fences...
Some things like
bindweed, regrow from short pieces, so tilling can create more divisions, and also transport them farther in the bed/plot. I've found it sprouting from just half-inch root fragments.
If the cinquefoil is tilled, is that just chopping up and replanting the runners?