I've noticed that some grafted fruits although they're bigger get more worms and the like. I don't spray of course and for me some of my wildish stuff is better. The taste is also sometimes better on plants grown from seed, some times vice versa too. If plants are grown for many generations without sexual reproduction serious problems can arise. just look at the banana and all the problems lately. I for one plan to grow bananas with seeds in them again and try to increase the quality of them rather than something that can't even sexualy reproduce anymore.
Note to self: don't get into a fist fight with a cactus. Command this tiny ad to do it: