Urine was thought to be sterile until relatively recently, when very sophisticated lab techniques showed incredibly small amounts of certain pathogens in urine. It is thought to be picked up in the urethra on the way out. If there is any bacteria or viruses in urine, you are diagnosed with a uti - urinary tract infection. For all practical purposes, urine can be considered sterile. The EPA and WHO do not consider urine to be a health risk, and it can be placed directly on agricultural for personal use. If you are a commercial farmer, the pee must be stored in a tank first for I believe 2 months. This is insurance, just in case someone with a serious uti donated their urine.