I have been searching the internet for information on whether paw paws can make one sick. I planted 2 saplings and 12 years later have loads of fruit - which I was eagerly awaiting. Big oops, though. I discovered that although I can tolerate raw paw paws - for example in delicious home made ice cream - baked paw paw items, such as paw paw bread, made me sick almost immediately, as in pull over while driving and throw up. Sorry for the details, but it was such an extreme and unexpected reaction!! And a lot of disappointment, too. It's all I can do to give them away. Lucky for me, I discovered the Wildlife Hospital in town will accept any and every paw paw. I guess the bears and other critters tolerate them very well.