P Colvin wrote:" Once the nettle has seeded, it is unsafe to use for making rennet. "
Why? Other sources cite the seeds as good nutrition, and I have made tea with seeded nettle, the whole plant.
As nettle plants mature to the flowering/seeding stage the leaves develop cystoliths, tiny crystals of (I believe) calcium carbonate that are insoluble in water and also indigestible, but depending on size can be absorbed. Ingesting too many of these can cause tiny tears in the body and cause irritation, especially the urinary tract, similar to having too many oxalates. This is why it is advised only young leaves in spring are harvested.