My two cents worth...after having taken two extra strength Naproxen Sodium caplets every day for about two years in an attempt to ease my knees' pain, I stumbled over the tidbit that it could cause the alarming edema that had suddenly shown up in my leg. That was 2015. I haven't taken an NSAID of any kind since. The edema promptly went away. This year (2021) I stumbled across the tidbit that too much of two amino acids (that were prominent in the collagen I added to my coffee) can aggravate inflammation. I cut out the collagen and noticed much lessening of pain. The most interesting improvements have recently shown up since I modified my vitamin supplementation; specifically B-3, Niacin. B vitamins are water soluble and your body can only use so much at a time. The excess is peed away. So my megadosing once or twice a day assured a supply "for the moment" and then an insufficiency after the excess had been flushed. I have noticed marked lessening of discomfort and increase of function since I began taking divided doses as frequently as every 90 minutes. Doses are different for everybody. You need to sort that out for yourself. Niacin: the real story, a book co-authored by Andrew Saul, is an excellent primer for that. I buy niacin in bulk powder form and spend about $0.04/ day on ten 136mg doses. The real expense is in the 10 interruptions you have to discipline yourself to do. Good results help with that. This isn't instantaneous, but neither were the causes of my knee issues. Other things do doubt have helped as well. No sugar, Organic food, time restricted eating, dropping about 15 pounds, multiple,multi-mile hikes each week. I'm 68 and doing much better than I did at 58.
