I have 4 autoimmune diseases (ITP, Graves disease, hashimotos & reynauds ) and my spine is in severe-advanced degeneration (low back & neck) My RA & Lupus test are negative and my Drs insist I have osteo arthritis. Anyways my Hematogist suggested I try tumeric. So I took 500mg capsule every 8 hrs x 2-3 wks. It brought on such a seering, burning, achy throbbing in all of my spine I had to stop it . I noticed previous nights that my benedryl 25 mg at bedtime for sleep helped tone down the terrible burning pain. I immediately started taking benedryl 50 mg every 6 hr & the burning spine pain subsided & was gone in 2 days.