Sure....the
permaculture triad of flower/herb/vegetable works particularly well in a
greenhouse because you also need to lure in pollinators. I do tomatoes as the vegetable because where I am summers are too cool, near the ocean, to get good crops of tomatoes. But I always get even better crops when there are flowers. In the case of tomatoes, the flowers have to be open in March/April when the tomato flowers start, for the earliest pollination. The
greenhouse has early blooming rosemary on both ends, that are not enclosed with panels, just
chicken wire and shade cloth if the wind needs to be blocked.
Some of the cherry tomatoes act like perennials, and overwinter (in my mild winter area) so they are blooming in March. I always start my own tomatoes from seed inside with a light table in December, so they are often blooming by the end of March.
Also
hugelkultur trenches during the winter, so the planting is easy come spring. The trenches turn into hot piles that keep the heat up in spring. I haven't had any issues with the soil by monocropping there, I think because of the hugelkulture input.
I don't put perennials in the greenhouse because I can alternate where I put the tomatoes/peppers, moving them over about a foot one year, then moving them back the next. It also gives me more room to move around in a confined space and its easier on the back.
The only issue I have in the greenhouse is when the packrats and
voles get in, and are protected, and eat the tomato plants. That's an ongoing thing.
An important distinction: Permaculture is not the same kind of gardening as organic gardening.
Mediterranean climate hugel trenches, fabuluous clay soil high in nutrients, self-watering containers with hugel layers, keyhole composting with low hugel raised beds, thick Back to Eden Wood chips mulch (distinguished from Bark chips), using as many native plants as possible....all drought tolerant.