I would make or acquire the best
compost I could (BEAM/Johnson Sunis my preferred method) and make compost extracts and aerated foliar teas with that. These can be mixed with organic fertilizers at a fraction of the concentration and have a similar benefit. The compost contains nutrients in the living organisms in it, and these cycle any other available soil,
water, and air borne nutrients many times over with the plant as a symbiotic partner. That or the plant literally consumes the microbe and consumes its nutrients, often with some spores or genetic material of the microbe surviving the process and benefiting from the plant’s growth and infusion of photosynthesized sugars.
Foliar feeding with aerated compost teas can be many times as efficient as soil applications (4-50+x depending on the nutrient according to John Kempf). This seems to me to be because they benefit both the surface of the plant and its ecosystem, and much of the runoff is then caught by the soil.
For water and nutrient holding capacity, I would look into
biochar and its use as an alternative to perlite or vermiculite. This combined with good compost can be the foundation of a potting mix, with sharp river sand added for drainage as needed.