Update to my version of Thom Bri's weevil experiment:
As I shelled my entire season's worth of mixed dent corn in my garage, all less than perfect kernels were thrown into an open topped cardboard box. This included all stained, dirty, moldy, bug damaged kernels or any that looked less than perfect, as well as a handful of good kernels that fell on the floor as I shelled. Overall, it contained an estimated 3 gallons by volume.
After a few months, I decided that instead of throwing away the whole box, I'd sort through it to select out all of the good plantable kernels that survived the weevils up to that point. I did find a few weevils in the bottom of that box, but felt that enough time had gone by that any eggs that were there would've hatched by then.
I sorted through the box kernel by kernel, inspecting for weevil holes, or any other real damage that would prevent the seed from growing. All told, I ended up with about a half gallon volume of good plantable seed from that entire box. I'm storing this seed in clear glass jars in my unheated garage so I can glance at it every time I walk by, looking for signs of weevils. So far, it's been about a month of cold temps with no new hatches. I don't expect new hatches until spring, but as the summertime temps rise, we'll see if they do hatch anymore after seasonal dormancy.
This may not be entirely scientific, but I think it's a practical test for myself and my purposes for the time being. If I do this same process of hand grading seed, allowing the hatch, grading what's left, then monitor what's left, I'm sure to learn something along the way. Even if this study doesn't result in developing a weevil resistant line of field corn many years from now, it's still a worthwhile experiment to pass the time and work toward corn that survived exposure to mold, weevils, frass, smut, lodging, weather, etc. with no fertilizers or chemicals.
On one hand, this goes against the idea of using perfect seed ala "best of the best" genetics.
On the other hand, it embraces the idea of exposing these same "best of the best" plant genetics (same OP gene pool) to stressors on the individual seeds that they have to survive in order to grow the next generation.
I look forward to hearing the results of Thom Bri's parallel experiment mentioned earlier in the thread. In the end, whatever is left in the jars will contribute to my continued diverse planting seed.
I'm open to hearing other thoughts, theories, experiments, or questions on this subject if you have them.