There is a significant difference between synthetic nitrites & natural nitrites found in vegetables.
https://www.seleneriverpress.com/historical/natural-versus-artificial-nitrates/
Personally I avoid using Tender Quick. It means I have to make smaller batches that will be used very quickly and also I add lots of celery, chopped as finely as possible, into the mix. Celery has high levels of natural nitrites.
I dont know it it protects me from botulism, but I do like the taste. (Tho my family accuses me of overuse of celery. In soups, etc. I even chop it up & put it under the skin of baked chicken. Would never make juice without it. Ive always loved it. )