This is probably late for the OP to make much use of, and maybe the climate is too different as well for much of it, but maybe it can still be of some use even if to someone else.
I haven't lived here long enough to really see how well different aspects work long term, but I'm more than satisfied with our home. The previous owners built our house while they had been running a small dairy for years. The layout is great. All the bedrooms are on the north side of the house, cooler and darker for better sleeping. The entrances on the main floor lead almost immediately to a wet room where someone could get hosed down. The main entrance has an enclosed unheated veranda surrounded by windows that can be used like a greenhouse in the summer. Then before entering the house, there's an airlock with the aforementioned wet rooms, as a buffer against winter cold. Whoever engineered the overhang length was spot on with little sun in the summer, but what little sun the winter has to offer lights up the whole of the south facing living areas. The plumbing could be better clustered, even allowing for the wet rooms in a different area of the house, but the hot water supply also heats for us, and all the non-radiator related plumbing is at least located on interior walls. Radiant heat is so much better for my health, not just more energy and cost efficient. The electrical panel is at the entrance, much easier to access than some dark corner of the basement. The basement includes a root cellar located next to the stairs with a vegetable drop hatch accessible from outside (I've seen similar setups for firewood). The stairwell is open to the main floor, which helps control moisture and direct heat up from the masonry oven. The basement walks out, but not such that it has full windows. There's another unheated room as a buffer there which is used as firewood storage. That room is enclosed with firedoors. The furnace room is also built to contain a fire. The same chimney is used for a masonry bread oven, a wood stove, and the furnace. The sauna has direct access to the back exit for a cool break on the porch or roll in the snow. The roof is metal with a permanent ladder and catwalk for chimney sweeping or shoveling if the snow load gets dangerous some winter. That was also really useful last summer when we had to put wire netting over the exhausts to keep the mosquitoes out. I like that the toilets are in rooms without a bathing option and the places where one could hose off, shower, or sauna do not include toilets. Growing up, I didn't like having to let family members in to use the toilet while I was bathing.
That all said, there are certainly things I would have done differently. I think radiant floor heating would be preferable to the radiators under the windows. We make use of rugs, slippers, and wool socks, but I wish I could have the say in getting rugs out of the kitchen space and radiant floor heating in the kitchen might help with that. The kitchen also has wood floors and wood does not wear well in such a utilized room. Our laundry and toilet rooms don't have floor drains like some places I've lived in the past, which would be peace of mind for potential leaks, though they get smelly if water circulates through them so infrequently that the dry up. I would get rid of some plumbing I find unnecessary, including water toilets. Someday, we hope to replace our hookups to city water back to our better tasting well and have a passive grey water system instead of lugging buckets and losing plenty of valuable resource to sewage. There are built in cupboard style closets in the bedrooms and in a couple of the rooms that makes access around the beds frustrating. I would have been happier with no closets/cupboards in the bedrooms and instead using a standalone movable wardrobe and dresser. At least that's easy to change once we get to it and those cupboards can be reused in the shop. Some of the overhead lighting is wired in a way that's nonsensical to me and not trivial to change. Pay attention to which way you want doors to swing because one door in the house swings the wrong way to me and blocks another doorway when open.
This last part is concern passed down to me from my mother who was always notifying city officials of sidewalks that weren't wheelchair accessible and handicap parking spaces that didn't meet code. Through her work met with people on a daily basis who could no longer live in the bulk of their home. While the necessary parts of the house are reasonably accessible (at least one bedroom on the same level as a kitchen and living space) and the shower is a wet room instead of a raised basin stall, it would be nice to include some more universal design elements, like outlets not so close to the floor, wider clearance in some of the doorways. Towel racks in bathrooms could discretely be assisted handrails/grab bars, though the wall construction has to support the weight. Consider pocket doors, which automatically give more clearance because the door isn't taking up space. The down side is that limits where wiring can be. Space under counters or sinks for wheel chair access could be retrofitted without too much difficulty in many cases, but not side to side clearance in bathrooms and hallways, a walker being able to sidestep is bare minimum. Universal design is worth looking into and ties in well with permaculture.