a big danger in removing a lot of
wood is that the tree tends to really push through the new graft(s) to even out its
roots. if you're not careful about staking/supporting the big new growth they can rip out in a wind. in general though, i think you
should go for it. it's not exactly the same thing, but i've done a number of the black walnut trees on my property by just cutting them off at 5 or 6 feet and rind grafting the stump. with walnuts, it works better when the trunk is maybe 5 inches or less, but pears are pretty forgiving with grafting of all kinds. great opportunity to practice a few things! do a handful of each kind of graft you're interested in, and you'll figure out your favorite grafts pretty quick.