When I picture my retirement, I often picture myself picking a handcart around my neighborhood.
I already have limited access to vehicles, so a lot of moving materials around the corner to my second yard has been accomplished by hand.
I currently have a best down bike trailer that I use, pulling it by hand.
I have built a chick-shaw as part of trying to comply with my cities chicken ordinances, which thankfully have changed.
I was not satisfied when I was done, but I learned a lot while doing it.
Wheelchairs are in relatively short supply compared to bicycles.
If you choose to support teach wheel on both side, making a cart with bicycle wheels is fairly simple.
With the use of an angle grinder the bike itself can donate the wheel holders, or they can be made of scrap steel, and either way, bolted to the carts structure.
I also think protecting the cargo from the wheel is important.
It doesn't add much weight, since the material needs to be stiff but doesn't need to be load bearing.
I think adding electric power makes sense if you live anywhere that's not flat.
A single powered wheel mounted in the rear, might be ideal.
This would allow it to be engaged/disengaged by the driver simply by pressing up or down.
It could probably be regenerative, recharged during braking.
Powering both wheels independently via chain drive also seems doable, but messy by comparison.