So I just got directed to this article by my wife (who only heats our goats' milk for yoghurt to body temp btw, no holder pasteurisation involved, and it's excellent). I figured I'd drop in a few additional comments regarding raw milk vs pasteurised milk along with sources.
The CDC records and reports the numbers of oubreaks of foodborne illness due to raw milk vs pasteurised. However, they don't generally report numbers affected. Raw milk is responsible for more outbreaks than pasteurised milk, but the numbers involved tend to be much smaller as the milk generally doesn't travel too far from the dairy. So where an outbreak caused by raw milk might affect 5-20 people, there are 2 notable outbreaks caused by pasteurised milk in the US which affected a total of 400,000 people (source: The Raw Milk Answer Book, by David E. Gumpert (available on Kindle, and a great source of info generally)).
There have been numerous studies linking the inverse relationship between consumption of raw milk and asthma. This has generally been put down to "the farming lifestyle" and have not directly attributed raw milk as the protective factor. However, a 2017 article shows a very strong direct correlation between the consumption of raw milk vs pasteurised milk in induced asthma attacks -
https://www.frontiersin.org/articles/10.3389/fimmu.2017.01045/full
A recent Japanese study tested the effects of enteric coated lactoferrin on obesity. In this case that's live lactoferrin in an enteric capsule (one that dissolves in the gut, not the stomach) which resulted in a significant reduction in median obesity. The same enteric properties are provided in raw milk by the fat globules, which protect the lactoferrin from the stomach acids on the way through in order to provide the infant with a healthy gut biome. The study used quantities of lactoferrin equivalent to that found in 100g of raw milk cheese. The study can be found at:
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/51329C1D9CD5F178654F84206A34311D/S0007114510002734a.pdf/potent_antiobesity_effect_of_entericcoated_lactoferrin_decrease_in_visceral_fat_accumulation_in_japanese_men_and_women_with_abdominal_obesity_after_8week_administration_of_entericcoated_lactoferrin_tablets.pdf
Regarding e-coli, I've got the results of the investigation into the last e-coli O157:H7 outbreak in Scotland. This occurred via raw-milk goats' cheese, and e-coli was found throughout the farm, including in the faeces of the goat that provided the cheese, and in the fridge that the cheese was stored in. However, it was *NOT* found in a milk sample taken directly from the animal under controlled conditions. This fits with the CDC's breastfeeding guidelines which show that raw human milk is safe with the exception of the following diseases: ebola (just don't breastfeed if you've got it), herpes simplex virus (similar to coldsores - don't breastfeed *if you have active sores on the breast/nipple*), and HIV (Which has a 0.17% chance per week of breastfeeding of being passed to the infant, with a significant increase in likelihood of infection due to cracked/bleeding nipples (blood transmission, not milk) or if the infant has sores in their mouth). As per
https://www.cdc.gov/breastfeeding/breastfeeding-special-circumstances/maternal-or-infant-illnesses/index.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fbreastfeeding%2Fdisease%2Findex.htm
On a further note on STEC infection (including e-coli O157:H7), one of the benefits of raw milk is the improvement in gut health, specifically the improvement in integrity of the intestinal barrier from drinking raw milk. The Shiga Toxin produced by O157:H7 causes lesions in the intestinal barrier (hence blood in the stool etc) and can go on to cause renal failure if it gets past that point. So the best defence against e-coli 0157:H7, ironically, seems to be drinking raw milk.
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/8CF3C0E4B3F7C89BB9A7830B8FE742A7/S000711451400107Xa.pdf/enteral_supplementation_of_bovine_lactoferrin_improves_gut_barrier_function_in_rats_after_massive_bowel_resection.pdf
Note that 2 of those articles relate to getting bovine lactoferrin into the gut. Raw milk does that. Standard 15 second @ 72 degrees C pasteurisation kills around 30% of lactoferrin and reduces the activity of the remainder by (iirc) 0-70%. Homogenisation destroys the integrity of the fat globules which would transport it to the gut. So while pasteurised milk contains the same stuff as raw milk, that's like saying the cat that I stuck in a blender is still a cat.
I also have a theory, unproven, but which fits with the CDC's statements on human breastmilk, that the preventative effect of raw milk on disease is significant, and that in many cases the idea that milk can contain pathogens so should be pasteurised is similar to the idea that you'd boil live vaccines because they contain pathogens. However, that also depends on the dairy - a commercial dairy that plans to pasteurise it's milk is unlikely to pay enough attention to excellent animal health and milking parlour conditions to ensure that the pre-pasteurised raw milk is actually safe to drink. Drink from the bulk tank there and you'd probably be a statistic.