On cuttings in water that's usually not powdery mildew, it's just regular mold that loves the moist conditions right at the waterline. Changing the water every couple of days is good but you could also try adding a tiny splash of hydrogen peroxide to the water, it keeps things cleaner without hurting the roots. The other thing that helped me was using a narrower vessel so less stem is exposed to damp air above the water. Perlite or vermiculite in a cup works well too if you want to get away from water propagation entirely, holds moisture without everything sitting wet.