Such a loaded question...when my kids are grown and flown I suspect gifts like the ones suggested here will be valued. My family is not of that ilk.
Over the years I've made the same thing for everyone, such as tweedy sewn owls, felted wool bowls/containers, painted silhouettes of kids, knitted hats, hand sewn Dopp kit bags, custom shearling shoe liners...little is well-received (DOPP kits were) so in 2020 we stopped pouring ourselves into handmade items and feeling bad about the whole thing. This year they will all get a silk pillowcase. I got them at a great sale price from an okay company and my husband (such a stodgy, er, minimalist) LOVES his silk pillowcase so I think it will go over well. The shift to consumerism does make me sad but we try to find something they may actually appreciate that we feel okay buying too. Too bad for them it all shifted just when I started making the BEST soap.
For others, we plan to gift my husband's really good hard cider or homemade cider syrup.