Some information on manuka honey and mrsa:
“Honey can make MRSA more sensitive to antibiotics such as oxacillin – effectively reversing antibiotic resistance. This indicates that existing antibiotics may be more effective against drug-resistant infections if used in combination with manuka honey.”
The researchers point out that honey is a complex and variable product, so searching for “specific inhibitors” (the molecular compounds that might have an effect on bacteria) has not been easy. They think that several factors may together be implicated in its antimicrobial activity, including its high sugar content, low water content, low acidity, the presence of hydrogen peroxide and the presence of phytochemicals.
Manuka honey is thought to be particularly potent because it has high levels of a compound called dihydroxyacetone, which is present in the nectar of manuka flowers. This chemical produces methylglyoxal, a compound thought to have antibacterial and cell-killing properties.
Overall, the researchers found that manuka honey affected the structure and activity of different bacteria.
In the study of MRSA, the bacteria were susceptible to “relatively low” concentrations of manuka honey. Combining honey with the antibiotic oxacillin (and to a small extent vancomycin) altered the structure of these drugs, making them potentially more effective. This was measured as the minimum inhibitory concentration or minimum bactericidal concentrations, which are each a measure of the concentration of drug needed to slow growth or kill the organisms.
In the study of Pseudomonas bacteria, the honey induced “significant changes” in the bacteria’s protein expression, which is likely to be detrimental to its survival.
In the study of Streptococcus pyogenes, honey inhibited the growth of bacterial biofilms.
http://www.nhs.uk/news/2011/04April/...-bacteria.aspx