The features that constitute Domain 2 A are:
Unusually soft or velvety skin
Mild skin hyperextensibility
Unexplained striae such as striae distensae or rubrae (I got stretch marks while pregnant, but no other time. I also have always grown very slowely and never had rapid weight gain, so not many other chances for stretch marks)
Bilateral piezogenic papules of the heel--I always wondered what those were!
Atrophic scarring involving at least two sites and without the formation of truly papyraceous and/or hemosiderotic scars as seen in classical EDS
Recurrent or multiple abdominal hernia
Pelvic floor, rectal, and/or uterine prolapse in children, men or nulliparous women without predisposing medical condition
Dental crowding and high or narrow palate
Mitral valve prolapse (MVP) mild or greater based on strict echocardiographic criteria
Arm span-to-height ≥1.05 AND/OR upper segment/lower segment ratio <0.89
Arachnodactyly, as defined in one or more of the following: (i) positive wrist sign (Steinberg sign) on both sides; (ii) positive thumb sign (Walker sign) on both sides; (iii) hand/height ratio > 11% on both sides; (iv) foot/height ratio > 15% on both sides
Aortic root dilatation with Z-score >+2 on echocardiography
Hypermobility is also seen in certain types of genetic HLA DR haplotypes. 11-3-52B, I work with people who have genetic mold sensitivities and this particular haplotype that is seen in 1% of the population is seen in 15% of the people who have mold sensitivities. I have also seen people who do not have a genetic reason or known disease causing their hypermobility, who become hypermobile and twist their ankle or get repeated and varied types of tendonitis etc when they are exposed to water-damaged buildings. These people are only hypermobile when they become inflamed from being in an environment that has mycotoxins or from exposure to other biotoxins. By the way, folks with HLA 11-3-52B should avoid the Gardasil vaccine and are more likely to be affected by various biotoxins such as mycotoxins, cyanobacteria, Lyme, and venom from some spiders and snakes.
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