Welcome to Permies! I'm sure you will get a lot of good ideas, after you give us some information about your land, climate and desires. A blank slate is hard to focus on
One thing that is a given is that it would be good to orient your house with the long walls facing directly north and south if you can do that on your site. A decent overhang on the south wall will keep the sun out all summer while letting it in in the winter (if you have real winter) minimizing cooling and maximizing free heat.
It sounds like you are planning standard stick construction and materials. Would there be anything you would build yourselves, either now or later? (Four teenagers are likely to want more space than you have

) What kind of lifestyle are you looking at? Animals, gardens, ??