Parameter | First-Order Biophase Model | Bolus Biophase Model | ||
---|---|---|---|---|

Estimate | CV% | Estimate | CV% | |

S_{max} | 249 | 1 | 190 | 7 |

K’ (first-order) (h^{−1}) K (bolus) (h^{−1}) | 5.96 | 4 | 2.54 | 6 |

SD_{50} (µg) | 1.02 | 4 | 1.43 | 8 |

n_{H} | 1.63 | 5 | 2.05 | 18 |

k_{out, max} (h^{−1}) | 30.1 | 4 | 32.9 | 4 |

k_{M} (h^{−1}) | 0.001 | 9 | 0.001 | 1 |

WSSR | 768 | 640 |

WSSR, weighted sum of squared residuals.