I don't have a scientific paper reference at hand for you, but I've read and listened to a lot of podcasts and such on the subject from soil scientists and plant experts. Apparently plants are lazy, like humans, and perfectly happy to grow on junk food ( synthetic NPK ). This leaves out the microbs feeding them and in the process secondary metabolites, minerals, flavonoids, etc... are lacking, and apparently water is takes up the space where these nutrients would be in the plant.
I don't know if this is what you're looking for?
Here's Dr. Christine Jones talk on the negatives of using artificial N. Around the 7:00 minute marks she addresses plants lacking nutrients.
Also google Dr. James White and the Rizophagy cycle on how plants harness microbs to get all the nutrients they need without artificial inputs.
John Kempf and Dan Kittredge are other good ones to look up.