I usually use recycled 4" pots, and have used soil blocks, and am getting back into them this spring. They can work great but you have less room for sloppiness.
Eliot Coleman makes the best case in his New Organic Grower (this man is not sloppy).
You are dependent on peat mining--unless you substitute
compost. I haven't experimented enough to know if you can get away from peat, and still create a compressed block that is penetrable by
roots.
I really like getting 50 starts from a flat that has room for only 20 4" pots
Once the dry out they are hell to wet. A mister would be good. I have also bottom watered with plastic flats in a basin made of plastic and scrap
wood. Too heavy a watering from overhead can erode young blocks. Don't let them get too dry!
They are pretty easy to handle, even when new, and quickly stabilize with roots.
I have a 1.5" four-block press--I could very easily see wanting more blocks per pressing if you were scaling up beyond home production.