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Hyaluronic acid, chondroitin and glucosamine

Sarah Joubert

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posted 5 hours ago

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I am researching how to increase the levels of these to help increase sinovial fluid and cartilage maintenance. For my mother who has osteoarthritis in her fingers primarily but elsewhere too, and my aging dog who is known to have hip displasia and has just broken her leg. Most of the info out there is "buy pills"- but be careful what you buy blah blah blah. At the end of the day, how do I know the body will absorb enough of the product to actually make a difference? I have read many of the mixed/poor results of trials -they all involve taking pills. My mother has taken pills - no difference. My dog can't tell me if they're helping or not.

To get it naturally shellfish and bone broth from high cartilage areas are reccomended. I want to try bone broth from cartilage rich foods like chicken necks and feet and prawns/shrimp/crayfish. What I cannot find is how to ensure you get the mg levels required to make a difference. The guielines are eat oily fish 2 -3 times a week and drink broth. I cannot find how much condroitin and glucosamine mg per ml the broth contains. So how do i work out a daily dose ? I do understand that all bone broths are not created equal but there must be a starting point somewhere-does anyone know it?

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M Ljin

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posted 3 hours ago

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A quick wikipedia brings up:

The average 70 kg (150 lb) person has roughly 15 grams of hyaluronan in the body, one third of which is turned over (i.e., degraded and synthesized) per day.[6]

So it sounds as if maybe one would need to eat it constantly to have benefits, if the issue is the body isn’t making enough of it.

Glucosamine is one of the most abundant monosaccharides.[2] It is produced commercially by the hydrolysis of shellfish exoskeletons or, less commonly, by fermentation of a grain such as corn or wheat.

Maybe this means it is present in sourdough bread? Or do they mean fermentation with “special” microorganisms, whatever that may be?

Chondroitin doesn’t have any notable information on the page.

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M Ljin

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posted 3 hours ago

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In certain forms of medicine, there sometimes is a focus on various qualities in the body, like moisture, dryness, heat, cold, etc. Osteoarthritis sounds like it would have something to do with lack of moisture—maybe not literally that the joints are dry, but that this quality of moisture is less present (if that makes any sense? It does to me)

Part of it might be resting the hands and making sure they have time to recover, and nourishing the kidneys, said to govern the body’s water. I don’t think sleeping well could be a bad thing, or drinking sufficient fluids, which might be broth or a nourishing tea. Both of those are rather moistening to the body.

Thinking more, horsetail keeps popping into my mind, which has a reputation for being good for connective tissue, and not only that but also is supportive of the kidneys. There is some information on my favorite websites, which supports the idea of using it for supporting the joints:

https://pfaf.org/user/Plant.aspx?LatinName=Equisetum+arvense
http://naeb.brit.org/uses/search/?string=Equisetum

I found it interesting to hear about native Alaskans harvesting large quantities of horsetail to feast on the stem juice. I tried last year and it is delicious! The plant reminds me via the doctrine of signatures makes me think of synovial fluid, and the overall jointed nature of the plant. Not that I am pushing or recommending the plant—I don’t have experience of using them for osteoarthritis. It could be something to try with further research and if it feels right.

One can never be too kind to oneself or others.

Sarah Joubert

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Posts: 208

Location: More D'Ebre, Tarragona, Spain Mediterranean zone

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posted 47 minutes ago

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M Ljin wrote:

The average 70 kg (150 lb) person has roughly 15 grams of hyaluronan in the body, one third of which is turned over (i.e., degraded and synthesized) per day.[6]

So it sounds as if maybe one would need to eat it constantly to have benefits, if the issue is the body isn’t making enough of it.

Glucosamine is one of the most abundant monosaccharides.[2] It is produced commercially by the hydrolysis of shellfish exoskeletons

Thank you M Ljin for that reference, it has enabled me to reserch more. This is what I have found:'
Commercially they use hydrochloric acid hydrolysis on crustacean chitin to extract the glucosamide with an average 40% yield rate from a 1/40 solid/liquid ratio. It's a complicated process involving heating, straining drying to get a powder form. The body then uses magnesium to synthesise Hyaluronic Acid in the body.
If the body uses 5g hyaluronan a day, that means the rda is 5000mg hyaluronan, how much glucosamine is needed to synthesise 5000mg hyaluronan?, how much bone broth would one need to consume daily?

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