There are so many possibilities that could be added into designs to help and care for its users. Many of my aunts, uncles, and grandparents are retired. I think permaculture could definitely be used to enrich their lives.
This video by Cozy Aum gives her voice and advice on doing permaculture with a disability:
Martin Giannini made a nice series about widening permaculture:
Geoff Lawton wrote an
article about a few considerations that can make permaculture work for the disabled, and on permies there was another
discussion similar to this one.