I have started my search for a few acres of land on which I could do part-time homesteading and continue my current job part-time.

I would prefer to live in a rural area, and am looking at some property that's in the middle of a farming area. The plot has definitely had pesticide/herbicide used on it, and the surrounding farms use it. I'm wondering how feasible it would be to set up a permaculture garden and small livestock operation.
I'm assuming that soil remediation on my own plot would be doable via adding in tons of
compost, manure, mulching, etc - basically building new soil on top of the old stuff.
What about pesticide that is blowing in from other farms? Would living fences help? Would they be enough?