They look like they have a little fungal growth on lower leaves, probably due t0 cooler weather than they like. Warm them up a bit by first spraying with diluted whole
milk on the leaves to kill the fungus (always use tepid or barely warm water for cukes or it shocks them too much). I had to cover mine with row cover cloth due to the cool nights. It buffers just
enough to keep them happy, also keeps that intense sun off during hot days, which they also don’t like. Make sure they have plenty of minerals in the soil to give them everything they need, plus a little
compost.
Strange weather patterns and sun is too intense, having to pay attention and adjust EVERYTHING. Row cover cloth suspended over lettuce in hot weather can keep it growing all summer. Just plant at two week intervals to keep it coming on.
With appropriate microbes, minerals and organic matter, there is no need for pesticides or herbicides.