When tomatoes were domesticated, they lost more than 95% of their genetic diversity. They are one of the most inbred crops that we currently grow. That makes them particularly difficult to use in a breeding
project, because they don't have
enough genetic diversity to start with. They can't shift much in response to new conditions. They are what they are, and all the breeding in the world won't change them into something else. At most, we get slight modifications to existing varieties.
Thousands or years of inbreeding, and the genetic bottlenecks along the way, made domestic tomatoes highly self-pollinating. Every time a plant self-pollinates, it sheds half of it's existing diversity. For that reason, breeding with self-pollinating domestic varieties felt like a doomed undertaking.
The desire to do actual breeding with tomatoes, enticed me to incorporate wild genetics into my breeding projects. I am selecting all varieties to carry the traits the require 100% out-crossing in every generation.