Hi Mike,
They use piperine in black pepper to increase the absorption of curcumin (a constituent in Turmeric). However, that is not all that is working in Turmeric. Curcumin is what has been studied mostly. It is rare to study Turmeric. The money is not in studying Turmeric as you can not patent it. I am going to paste some data from my "Herbal ABC's" book here to give you an idea of why their thinking is myopic. Other constituents such as tumerone also help it absorb - tumerone is already in turmeric.
Recent research has shown that the presence of the relatively lipophilic turmerone (a constituent in Turmeric) appears to facilitate the absorption of curcumin into colonic cells in vitro. It is not surprising that nature would put a constituent into an herb that would help another constituent in the herb be better absorbed. There are often multiple substances in an herb that act synergistically together and why herbalists often use whole herbs rather than individual extracted ingredients.
In a scientific study,
mice with colon tumors were given an alcohol extract of Turmeric (whole plant) with bevacizumab which was compared to a curcumin (considered the only active ingredient by some people who want to
sell it to you) product with bevacizumab. The plasma curcumin level of the turmeric extract-fed mice was the highest,
suggesting the alcohol, whole turmeric extract had better bioavailability than the constituent curcumin. Additionally, the alcohol Turmeric extract plus bevacizumab significantly inhibited the tumor growth and had no observable side effects.
So, as you can see, they did not give piperine or black pepper and still the whole extract of Turmeric performed wonderfully.
Now, I am not saying curcumin is bad, but it has a lot of hype. It is simply poorly absorbed and that study I just mentioned could be the result of other constituents all acting together for the result obtained.
Here is more on curcumin and enhancing absorption:
Curcumin has been formulated with bromelain for increased absorption as well as enhanced anti-inflammatory effect. Another form that has become popular is the use of the phytosomal curcumin which has also shown better bioavailabilty. I have used the phytosomal form for inflammatory conditions and find it works quite well, but prefer to use it with whole Turmeric. Mixing curcumin with piperine from black pepper has also been found to increase curcumins activity.
Curcumin undergoes glucuronidation which is thought to make it less active and cause it to be removed from the body more readily. Piperine which is found in black pepper inhibits glucuronidation in rats and guinea pigs. Therefore piperine has been thought to make curcumin more bioavailable when the two of them are given together. When piperine has been given to humans and rats at the same time as curcumin, it has enhanced the bioavailability of curcumin by 2000% in humans and 154% in rats. It has been thought to be due to inhibition of glucuronidation by the piperine, although research now shows additional possible mechanisms, such as enhanced absorption/bioavailability due to decreased P-glycoprotein activity.
There is a lot of research on the use of piperine from black pepper with curcumin showing the combination can prevent or alleviate a variety of diseases. However, I have to wonder if using piperine, eating a lot of black pepper, or anything else that is meant to decrease glucuronidation, could backfire on a person and lead to other health issues.
Inhibitors of glucuronidation may expose a person to the ravages of toxins. One has to ask themselves if this is truly a good idea or not. I think we need more data to know for sure. It appears colon cancer might be increased in people when there is inhibition of glucuronidation activity. I am also uncomfortable with decreasing P-glycoprotein activity or other types of Phase III cellular “pump” activities in the long term without more consideration of the ramifications of these actions. For some individuals using piperine or Black pepper as an herbal medicine to enhance bioavailability of curcumin may be helpful, while for others it could lead to additional future health issues.
Meriva®, a curcumin complexed with phospholipids, is a product I have used that uses phytosomal or lipids to enhance absorption.
There are some studies with Turmeric alone and often they have good results such as this one: In a clinical study of stomach ulcers using the powdered, dried herb, 600 mg, of Turmeric taken 5 times daily, one half hour before meals and at 4:00 PM and bedtime for 4 weeks provided superb healing. Ulcers were absent at 4 weeks in 48% of the patients, and 76% of the patients had no ulcers at 12 weeks. They only received the herb for 4 weeks, yet improvement continued after removal of the turmeric.
I also have had patients who used only Turmeric. Usually, heavily in their food and have found it to be a wonderful anti-inflammatory all by itself. It is my belief that there are other constituents beyond curcumin that are working and that is why it works for a variety of ailments that people think only curcumin mixed with something to help absorption will work for.
Did I make this clear as mud? I realize this is a bit of a complicated topic and I sure don't have the answers. I mostly have questions about this. I am 60 years old and have seen a particular process take place numerous times where companies studying constituents get everyone excited about certain plant constituents and sell them by themselves, sometimes with a patent and always charging more. Then it is eventually found that the single constituent is not as good as the whole herb after people were using the expensive constituent for years. Some multi-constituents that are for sale work well like with the plants Ginkgo and Milk thistle. However, the silymarin sold from Milk thistle is no better than the whole herb in my opinion, so even if it works well, why pay more. They seem to work fairly equal in actual use. With Ginkgo, the use of the leaves is new and in reality using the leaves without processing gives many people a headache and is not a good idea to use very much of them. The raw leaves have been known to cause headaches and the raw standardized product may also cause headaches depending on how it is processed. The European standardized herbs are processed in a manner that is less likely to cause headaches. So, I always suggest people use 24% standardized European sourced Ginkgo products sold on the market.
The issue I have with the pepper is simply that it is very good at stopping glucuronidation and that is a necessary route our cells use to detox. You can read more about this process here:
https://youarethehealer.org/health-conditions/optizmize-your-health/detox-biotransformation-pathways/glucuronidation/ No one knows if this is safe. We are all guinea pigs while using curcumin with black pepper or piperine (the constituent from black pepper usually added to curcumin) . I think it will be fine for some people and possibly even helpful when used to increase absorption of some herbs, but for others it will probably lead to cancer as it appears it may do with colon cancer.