One ibuprofen will put me out for the night, so I don't take anything for pain unless I have a full day to recuperate.
A few weeks ago I turned too fast (trying unsuccessfully to get to my landscaping before the electrical team could rip everything up) and it wasn't until I stopped moving that I realized something was wrong. By the time I got back into the house I was limping, and when I sat down it turned into what felt like a major and ongoing cramp in my calf muscle. I immediately wrapped it and kept heat on it for a while, until the cramp went away, then walked (carefully) on crutches for a few days.
My suggestion would be, listen to what your body is trying to tell you. In my case, after the initial injury phase the cramp was worse when I put my weight on my heel--i.e., when the muscle was stretched. There was no pain in ligaments or tendons, although they did stiffen up after a few days of not being used. Strange as it may seem, I wore heels for a couple days because when walking in heels most of the weight is on the toes. The incident certainly drew attention to the oddities of the way I walk, because I often walk toe first on one foot and heel first on the other--of
course, the heel-first foot was the one injured.
Similarly, when I throw my back out I look at myself in the mirror. Almost invariably one side will be lower than the other. I wear a shoe or a slipper on that "low" side, which evens things up and allows the muscles to heal without being strained every time I move. Interestingly, the "heel" and "toe" sides match up with the low and high sides when I throw my back out. I also have a rather high bed I can roll out of either onto my knees or into a crouch, making it easier to get out of bed if my back is messed up.
Pain can usually be mitigated or avoided altogether by simple precautions and preventative maintenance, making pain medications unnecessary except in extreme circumstances.