Christopher, my shop is 2,000 sq ft with 15' high ceiling with modest insulation. You're planning 6,000 sq ft. but you haven't given a ceiling height to determine the cu ft. Have you looked at Peter's website and the Building page with detailed specs for sizes up to a 10" system?. That same page provides some calculations for a given volume and temperature differential performance to provide guidance and help you to determine if a single system will be sufficient or if perhaps 2 will be needed.
https://batchrocket.eu/en/building
If you happen to know a plumber that installs hydronic heating systems they should also be able to run a BTU requirement calculation for you. I would think that one 10" system my be sufficient based on the numbers published by Peter. You can see that a 10" system has more than 4 times the thermal energy output versus a 6" system like I am running. With that said, it would be good to have someone with the knowledge to run the BTU calculations confirm this for you.